Abstract： Objective:To investigate the effect of hyperbaric oxygen（HBO）on bladder function after extensive hysterectomy for cervical cancer.Methods:A total of 100 patients with cervical cancer who underwent extensive hysterectomy in the department of gynecology of Yantai Yuhuangding Hospital from January 2020 to June 2021 were selected as the research subjects. They were randomly divided into HBO group（ n=50）and control group（ n=50），according to the random number table method. The control group was given conventional treatment，while the HBO group was treated with HBO on the basis of the treatment in the control group. The failure rate of the first catheter removal，residual urine volume after the first failed catheter removal，repeated catheter removal attempts，duration of indwelling urinary catheter，incidences of urinary retention and urinary tract infection，and the urodynamic changes were observed. Results:The failure rate of the first catheter removal in the HBO group（46%）was lower than that in the control group（58%），but the difference was not statistically significant（ P>0.05）. The residual urine volume after the first failed catheter removal in the HBO group was significantly lower than that in the control group［（279.79 ± 122.48）ml <（378.27 ± 174.79）ml］；the number of repeated catheter removal attempts in the HBO group was significantly lower than that in the control group［（2.57 ± 0.79）times <（3.29 ± 1.08）times］；the duration of indwelling urinary catheter in the HBO group was significantly shorter than that in the control group［（18.50 ± 4.29）d <（22.18 ± 5.23）d］；and the incidences of urinary retention and urinary tract infection in the HBO group were significantly lower than those in the control group（12% < 28%，and 4% < 18%，respectively）；all the differences were statistically significant（ P<0.05）. The postoperative bladder initial sensory capacity in the HBO group was significantly lower than that in control group［（143.34 ± 10.99）ml <（150.52 ± 22.33）ml］；the maximum postoperative bladder capacity in the HBO group was significantly lower than that in the control group［（377.06 ± 27.68）ml <（397.16 ± 39.82 ml）］；the postoperative bladder compliance in the HBO group was significantly higher than that of the control group［（48.10 ± 9.74）ml/cm H 2O <（43.60 ± 9.41）ml/cm H 2O］；the maximum postoperative urinary flow rate in the HBO group was significantly higher than that of the control group［（15.64 ± 1.89）ml/s >（13.96 ± 1.94）］ml/s］；and the detrusor pressure at the maximum urinary flow rate in the HBO group was significantly higher than that in the control group［（33.54 ± 2.70）cm H 2O >（29.64 ± 4.71）cm H 2O］；all the differences were statistically significant（ P<0.05 or P<0.01 or P<0.001）. Conclusion:HBO therapy after extensive hysterectomy for cervical cancer can effectively improve urodynamics，enhance the bladder function，and reduce the attempts of repeated catheter removal，the duration of indwelling urinary catheter，and the incidence of urinary retention.