Abstract： Objective:To build a mathematic model for calculating the heliox saturation diving decompression table.Methods:Based on the Haldane’s gas theory, this study analyzed the equilibrium condition of forces on the surface of bubbles in tissues to deduce the safety residence time of each decompression stop controlled by the safe excess pressure. Then, a calculating method of heliox saturation diving decompression table was obtained.Results:The decompression table calculated in this study has a higher desaturation efficiency compared with the British Royal Navy’s table; and it has a more reasonable decompression time distribution and better depth extrapolation compared with the US navy’s table. This table has been verified by more than 60 man-time (8 person times deeper than 300 msw) heliox saturation diving, and no decompression sickness occurred.Conclusion:The mathematic decompression model built in this study has the significance of determinacy in physics. It has many advantages in time distribution, depth extrapolation, and overall safety.