Abstract： Objective:To observe the clinical effect of traditional Chinese medicine (TCM) decoction supplemented with ultrashort wave and CO 2 laser intervention in the treatment of knee osteoarthritis. Methods:A total of 120 patients with knee osteoarthritis were randomly divided into treatment group (TCM decoction combined with ultrashort wave and CO 2 laser intervention group) and control group (ultrashort wave and CO 2 laser intervention group), with 60 patients in each group. The treatment group was given oral TCM decoction, 100 ml each time, twice a day, combined with ultrashort wave and CO 2 laser treatment, once a day, 4 weeks make a course of treatment. The control group only received ultrashort wave therapy and CO 2 laser treatment, once a day, 4 weeks make a course of treatment. The patients were evaluated by the visual analogue scale (VAS) before and after treatment. Results:The differences of VAS scores between the treatment group and the control group before and after treatment were all statistically significant ( P<0.01). After treatment, the VAS of the intervention group (2.63±0.76) was lower than that of the control group (3.53±0.73), with statistically significant difference ( P<0.05). The cure rate of the treatment group (61.7%) was significantly higher than that of the control group (50.0%), with statistically significant difference ( P<0.05). Conclusion:The curative and analgesic effects of TCM decoction combined with ultrashort wave and CO 2 laser intervention were superior to those of ultrashort wave and CO 2 laser in the treatment of knee osteoarthritis, which is worthy of clinical popularization and application in clinic.