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雾化吸入布地奈德对心脏瓣膜置换术患者炎症反应的影响
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Nautical Medicine and Hyperbaric Medicine
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1009-6906.2016.06.021
- Key Word:
- No keyword available
Abstract： 心脏外科手术大多需要体外循环(cardiopulmonary bypass,CPB)技术的支持,但CPB可诱发全身非感染性炎性反应,称为全身炎性反应综合征[1].全身应用糖皮质激素可减轻全身炎性反应,在CPB手术中应用较广泛,但不良反应较大,其在CPB应用的价值也遭到了质疑心-3].布地奈德是一种具有强效糖皮质激素活性和弱盐皮质激素活性的皮质类固醇药物.有研究[4]表明,布地奈德能减少儿童CPB后肺泡灌洗液中白细胞介素-6(IL-6)和白细胞介素-8(IL-8)水平.本研究观察单次雾化吸入布地奈德能否抑制CPB患者的炎症反应,为临床防治CPB术后炎症反应提供一种新方法.
- [1]刘建民.心脏瓣膜置换术后肺部并发症病因及诊治的研究进展[J].2013,(18).
- [2]林柏松,张秀和,张柏民,等.自体肺体外循环与常规体外循环对细胞因子影响的实验对比研究[J].2010,(3).
- [3]刘建东,王刚,陈婷婷,等.乌司他丁对心脏瓣膜置换术患者炎性因子的影响[J].2009,(1).
- [4]Pierpaolo Giomarelli,Sabino Scolletta,Emma Borrelli,etc.Myocardial and lung injury after cardiopulmonary bypass: role of interleukin (IL)-10[J].2003,76(1).
- [5]Werther Brunow de Carvalho,Marcelo Cunio Machado Fonseca.Steroids use in pediatric cardiac surgery: More questions[J].2007,8(5).
- [6]Silkoff PE,Uryniak T,Kemp J,etc.Asthma control in pediatric patients treated with once-daily or twice-daily nebulized budesonide inhalation suspension (Pulmicort Respules).[J].2008,29(3).
- [7]Ju,N.Y.,Gao,H.,Huang,W.,etc.Therapeutic effect of inhaled budesonide (Pulmicort? Turbuhaler) on the inflammatory response to one-lung ventilation[J].2014,69(1).
- [8]Watson RB,Guyre PM,Beach M,etc.Glucocorticoid effects on the inflammatory and clinical responses to cardiac surgery.[J].2002,16(2).
- [9]Judith L. Kristeller,Arthur Jankowski,Travis Reinaker.Role of Corticosteroids During Cardiopulmonary Bypass[J].2014,49(3).
- [10]Efstratios E, Apostolakis,Efstratios N, Koletsis,Nikolaos G, Baikoussis,etc.Strategies to prevent intraoperative lung injury during cardiopulmonary bypass.[J].2010,5.