Abstract： Objective To investigate the effects of drug triple therapy combined with bifidobacterium and lactobacillus triple live bacteria on the radical treatment of Helicobacter pylori (Hp) among the seafarers.Methods In accordance with the wishes of the patients,126 Hp-infected cases with peptic ulcer were divided into 2 groups.The control group was treated with lansoprazole,clarithromycin and amoxicillin for a succession of 2 weeks.The therapeutic group received lansoprazole,clarithromycin and amoxicillin combined with bifidobacterium and lactobacillus triple live bacteria,also for a succession of 2 weeks.All the patients in both groups were detected with 13 C-urea breath test and gastroscopy,4 weeks after withdrawal of the drug,and observations were made on Hp eradication rate,peptic ulcer heal rate and rate of adverse reactions in the patients of both groups.Results For adverse reactions in the gastrointestinal system of the therapeutic group,incidence of nausea,abdominal distention,diarrhea and parageusia accounted for 41.7％,46.7％,25.0％and 30.0％ respectively,while the data for the control group were 73.6％,66.0％,52.8％ and 56.6％respectively.Statistical significance could be noted,when comparisons were made between the 2 groups (P ＜0.05 or P ＜0.01).Following 4 weeks of treatment,peptic ulcer heal rates of both groups were 90.57％ and 95.00％ respectively,without statistical significance(P ＞ 0.05).In accordance with intention-to-treat (ITT) and per-protocol (PP) analyses,eradication rates for the control and therapeutic groups were 71.4％ and 84.1％,84.9％ and 88.3％ respectively,without any statistical significance (P ＞ 0.05).Conclusions Drug triple therapy combined with bifidobacterium and lactobacillus triple live bacteria failed to increase the healing rate of ulcer and eradication rate of Hp in seafarers.However,it could obviously decrease adverse reactions in the gastrointestinal system induced by drug triple therapy and helped to increase the compliance of patients.