Abstract： Objective To observe effects of hyperbaric oxygen (HBO) therapy on the indices of non-overt disseminated intravascular coagulation (DIC) induced by endotoxin in rabbits.Methods Forty-eight New Zealand rabbits were randomly divided into 4 groups,each consisting of 12.The first group (the control group) and the second group (the HBO control group) were given 10 ml NaCl with a concentration of 0.9%through ear edge vein.The third and the fourth group were administered endotoxin (100 μg/kg),through ear edge vein to induce non-overt DIC model.The 4th group was non-overt DIC+HBO group.The second and the fourth groups were given HBO treatment,twice a day,totaling 6 times.Blood samples were taken from ear central artery of each group either before injection of 0.9% NaCl/endotoxin,or after injection at hour 6,12,24,48,72 to detect indices of disseminated intravascular coagulation (DIC):platelet,prothrombin time (PT),activated partial prothrombin time (APTT),fibrinogen (FIB) and D-dimer.Results Platelet and FIB in the non-overt DIC group at corresponding time points were significantly lower than those of the control group and the HBO control group(P<0.05 or P<0.01),while the same indices of the non-overt DIC+HBO group dropped less significantly than those of the non-overt DIC group.However,statistical significance could be seen in cresttime.when a comparison was made between the two groups (P<0.05 or P<0.01).PT,APIT,D-dimer in the non-overr DIC group at corresponding time points all increased significantly than the control group and the HBO group(P<0.05 or P<0.01),while the same indices of the non-overt DIC+HBO group increased less significantiv than those of the non-overt DIC group,with statistical significance in crest-time,when a comparison was made between the two groups (P<0.05 or P<0.01).Conclusions HBO could effectively enhance recovery of platelets,PT,APTT,FIB,D-dimer in rabbits.