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Experimental study on the relationship between HBO with blood brain barrier permeability
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1009-6906.2006.04.007
- Key Word:
- 高压氧;血脑屏障;GM-1;神经保护剂
Abstract： 目的 探讨常规治疗压力(0.25 Mpa)的高压氧增强血脑屏障开放、促进神经保护剂(神经节苷脂,GM-1)进入脑组织的作用.方法 30只Wistar雄性大鼠,随机分为对照组、实验-1组、实验-2组、实验-3组、实验-4组;利用HPD 1700流体撞击仪,建立颅脑损伤动物模型,经毛细管电泳仪测定各组脑组织匀浆中GM-1相对浓度.结果 各HBO治疗实验组GM-1浓度较无HBO治疗组和对照组有一定程度的提高,但对照组与各实验组、各实验组之间q检验均没有显著差异(P＞0.05).结论 常规治疗压力的高压氧无明显促进BBB通透性作用,但有增加BBB开放的趋势,促进神经保护剂进入脑组织.
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