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Experimental research on the effects of Engraulis japonicus extractum ( fish sauce) on blood glucose and weight of rats
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1009-6906.2006.01.008
- Key Word:
- 鳀鱼提取物(鱼酱油);血糖;体重
Abstract： 目的研究鱼酱油对实验性糖尿病动物是否具有降血糖作用.方法用体重为200～220 g的SD大鼠200只,禁食24 h,尾静脉注射四氧嘧啶60mg/kg,建立高血糖模型.观察高剂量(5ml/kg)、中剂量(2.5 ml/kg)和低剂量(1.25 ml/kg)鱼酱油对实验性糖尿病大鼠空腹血糖和糖耐量的影响.用正常SD大鼠观察高剂量鱼酱油对正常大鼠的体重及血清Cr,BUN,GPT,GOT等指标的影响.结果连续给予高、中、低剂量鱼酱油30 d,对高血糖大鼠空腹血糖均无明显影响(P＞0.05),但可引起糖尿病大鼠糖耐量试验的血糖曲线下面积明显下降(P＜0.01或＜0.05);连续给予高剂量鱼酱油45 d,引起正常大鼠体重增长减慢(P＜0.05).结论高、中、低剂量鱼酱油均可降低高血糖大鼠糖耐量试验中的血糖曲线下面积,即提高受试动物的血糖耐受水平;高剂量(5 ml/kg)鱼酱油可减慢正常大鼠的体重增长.
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