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川崎病血管内皮细胞损伤机制的研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Pediatrics

Issue:: 2

DOI:: 10.3760/cma.j.issn.0578-1310.2016.02.020

Key Word:: No keyword available

Abstract：川崎病是一种以全身血管炎为主要病变的急性发热出疹性疾病,其特征为广泛的中小血管炎症,以心血管系统的损害最为严重.血管内皮细胞的损伤与功能障碍是血管炎发生的始动环节.血管内皮细胞的炎症免疫损伤主要指内皮细胞在一系列的刺激因素作用下,表达并释放如细胞间黏附分子1(ICAM-1)、血管细胞黏附分子1(VCAM-1)、E-选择素、p-选择素、L-选择素等黏附分子,以及癌胚抗原相关的细胞黏附分子,上述黏附分子引起循环单核细胞、中性粒细胞黏附于内皮细胞表面,继而进入细胞内膜,并激活补体结合而损伤内皮细胞.本文从细胞因子及免疫信号传导通路方面对川崎病血管内皮细胞免疫性损伤机制做一综述.

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