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肺炎支原体社区获得性呼吸窘迫综合征毒素研究进展
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Pediatrics
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.0578-1310.2013.07.022
- Key Word:
- No keyword available
Abstract： 一般认为肺炎支原体(MP)主要通过黏附到宿主表面、细胞毒作用、分子模拟和抗原变异等致病[1-2],但其确切的致病机制仍有待阐明.与其他细菌不同的是,至今一直没有发现与MP致病直接相关的毒力因子.2005年Kannan等[3]有关MP社区获得性呼吸窘迫综合征毒素(community-acquired respiratory distress syndrome toxin,CARDS TX)的发现填补了这个空白,并为进一步阐释MP致病机制提供了新思路.现就CARDS TX的研究进展做一综述.
- [1]Medina,J.L.,Coalson,J.J.,Brooks,E.G.,etc.Mycoplasma pneumoniae CARDS toxin induces pulmonary eosinophilic and lymphocytic inflammation[J].2012,46(6).
- [2]R Doug, Hardy,Jacqueline J, Coalson,Jay, Peters,etc.Analysis of pulmonary inflammation and function in the mouse and baboon after exposure to Mycoplasma pneumoniae CARDS toxin.[J].2009,4(10).
- [3]Kannan TR,Coalson JJ,Cagle M,etc.Synthesis and distribution of CARDS toxin during Mycoplasma pneumoniae infection in a murine model.[J].2011,204(10).
- [4]Kannan TR,Baseman JB.ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae represents unique virulence determinant among bacterial pathogens[J].2006,103(17).
- [5]You-Sook, Youn,Kyung-Yil, Lee.Mycoplasma pneumoniae pneumonia in children.[J].2012,55(2).
- [6]Baseman JG,Brooks EG,Baseman JB,etc.Persistence of Community-Acquired Respiratory Distress Syndrome Toxin-Producing Mycoplasma pneumoniae in Refractory Asthma.[J].2011,140(2).
- [7]Baseman JB,Muir MT,Cohn SM,etc.Novel toxin assays implicate Mycoplasma pneumoniae in prolonged ventilator course and hypoxemia.[J].2011,139(2).
- [8]Techasaensiri,C.,Tagliabue,C.,Cagle,M.,etc.Variation in colonization, ADP-ribosylating and vacuolating cytotoxin, and pulmonary disease severity among Mycoplasma pneumoniae strains[J].2010,182(6).
- [9]Coreen, Johnson,T R, Kannan,Joel B, Baseman.Cellular vacuoles induced by Mycoplasma pneumoniae CARDS toxin originate from Rab9-associated compartments.[J].2011,6(7).
- [10]Kannan TR,Musatovova O,Balasubramanian S,etc.Mycoplasma pneumoniae Community Acquired Respiratory Distress Syndrome toxin expression reveals growth phase and infection-dependent regulation.[J].2010,76(5).
- [11]Hardy RD,Salvatore CM,Katz-Gaynor K,etc.Intranasal interleukin-12 therapy inhibits Mycoplasma pneumoniae clearance and sustains airway obstruction in murine pneumonia.[J].2008,76(2).
- [12]Atkinson TP,Balish MF,Waites KB.New insights into the pathogenesis and detection of Mycoplasma pneumoniae infections.[J].2008,3(6).
- [13]Cover TL,Blanke SR.Helicobacter pylori VacA, a paradigm for toxin multifunctionality[J].2005,3(4).