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Nasopharyngeal carriage status of common pathogenic microorganisms in healthy children and its clinical significance
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PEDIATRICS
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.0578-1310.2002.01.111
- Key Word:
- 鼻咽;聚合酶链反应;儿童;支原体,肺炎;呼吸道合胞病毒
Abstract： 目的了解健康儿童鼻咽部常见致病微生物携带状况,探讨小儿呼吸道感染病原诊断中鼻咽分泌物检测的临床价值及依据.方法对2 294名健康儿童及患儿取咽拭子或抽吸鼻咽分泌物进行检测.其中1 906名儿童之咽拭子标本用聚合酶链反应(PCR)法检测肺炎支原体(MP);307名儿童取咽拭子行细菌培养;81名儿童取鼻咽分泌物(NPS)进行呼吸道合胞病毒(RSV)及腺病毒(ADV)分离.同期对患儿也进行了相应病原检测.结果 1 906名健康儿童中肺炎支原体阳性者28名,占1.47%;而544例急性下呼吸道感染者中阳性者107例, 占19.67% ,P＜0.001.健康儿童中肺炎链球菌、流感嗜血杆菌、金黄色葡萄球菌、表皮葡萄球菌、A组乙型溶血性链球菌(GAS)的平均带菌阳性率分别为18.6%、6.5%、2.3%、2.0%、2.0%,未发现脑膜炎双球菌;34例急性扁桃体炎患儿GAS阳性者26例,占76.5%,P＜0.001.81名健康婴幼儿呼吸道合胞病毒携带者3例,占3.7%,呼吸道3、7型腺病毒携带者1例占1.2%;而136例下呼吸道感染患儿RSV中阳性者51例,占37.5%,P＜0.001.结论健康儿童鼻咽部肺炎支原体、腺病毒、呼吸道合胞病毒、A组乙型溶血性链球菌及脑膜炎双球菌的携带者均很少,检测阳性者,有重要诊断意义;肺炎链球菌及流感嗜血杆菌等在健康人中的检出率较高,不能代表呼吸道感染的病原菌,但应密切结合临床分析,给予必要的重视.
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