Abstract： Objective:To investigate the effects of functional electrical stimulation(FES)combined with virtual reality(VR)training on functional recovery in patients with hemiplegia after stroke.Methods:This study was a prospective study, and 104 stroke patients with hemiplegia were selected from the rehabilitation department of Weihai Central Hospital from January 2019 to January 2022, there were 54 males and 50 females, aged(45.25±4.84)years old, ranging from 25 to 81 years old.They were divided into two groups according to the method of random number table, with 52 patients in each group.The patients in routine treatment group were received routine training, while the patients in VR group were received FES combined with VR training on the basis of routin training.The anxiety and depression[hospital anxiety and depression scale(HAD)], living ability(Barthel index), walking ability[functional ambulation classification(FAC)]and physiological indexes[including physiological cost index(PCI)and six minutes walk distance(6MWD)]of two groups were compared after two months of training.Results:After 2 months of training, the HAD score of patients in VR group[(9.89±1.35)scores]was lower than that in routine treatment group[(12.41±2.34)scores]. Barthel index[(61.66±6.13)scores]was higher than that in routine treatment group[(42.13±4.46)scores], PCI of patients in VR group[(0.41±0.09)b/m]was lower than that in routine treatment group[(0.57±0.11)b/m], and 6MWD[(312.66±36.75)m]was higher than that in routine treatment group[(292.13±24.79)m], and the differences were statistically significant( P<0.05). After 2 months of training, there was a statistically significant difference in FAC grades between two groups , the difference was statistically significant( P<0.05). Conclusions:FES combined with VR training for stroke patients with hemiplegia can significantly improve their physiological , relieve their negative emotions and restore their walking ability.This combined training method is a high-quality training measure and has important clinical application value.