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长链非编码核糖核酸母系表达基因3信号网络调控冠状动脉粥样硬化性心脏病的研究进展

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Author:: No author available

Journal Title:: China Clinical Practical Medicine

Issue:: 4

DOI:: 10.3760/cma.j.cn115570-20210427.01233

Key Word:: 长链非编码核糖核酸;母系表达基因3;冠状动脉粥样硬化性心脏病;动脉粥样硬化;炎症反应;氧化应激

Abstract：心血管疾病发病率高，是世界范围内重大的公共卫生问题，长链非编码核糖核酸(lncRNA)在心血管疾病的基因编程和基因调控中扮演着重要角色。lncRNA母系表达基因3(MEG3)是近年来发现的非编码核糖核酸，其在冠状动脉粥样硬化性心脏病(CHD)患者中表达异常，在CHD发生发展及疾病的诊断和预测方面具有重要价值，与CHD的严重程度及预后相关，可以作为CHD的临床诊断标志物及治疗靶点。lncRNA MEG3通过调节内皮损伤、心肌凋亡、动脉粥样硬化、炎症反应等病理改变，在CHD中发挥作用，然而MEG3调控CHD的确切分子机制尚处于初步研究阶段，未来需要进一步验证这些基因通路。本文对lncRNA MEG3信号通路调控CHD的研究进展作一综述。

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