Paper - WANFANG MED ONLINE

You Position: Home > Paper

认知功能障碍与慢性肾疾病相关性的研究进展

( views:83, downloads:76 )

Author:: No author available

Journal Title:: China Clinical Practical Medicine

Issue:: 2

DOI:: 10.3760/cma.j.cn115570-20191031-0001183

Key Word:: 轻度认知功能障碍;痴呆;肾小球滤过率;血肌酐;胱抑素C;白蛋白尿

Abstract：由于人口老龄化逐渐加重，认知功能障碍(CI)已经成为主要的公共卫生问题之一。CI主要包括轻度认知功能障碍(MCI)及痴呆。目前，CI不可逆转且治疗方法有限，筛查高危人群并在早期对风险因素进行干预显得尤为重要。慢性肾疾病(CKD)是认知功能下降的危险因素之一，CKD患者认知功能下降的风险增加，提示对CKD和血管疾病的预防可以降低后续认知障碍的风险。本文总结了CI与CKD主要生物标志物[肾小球滤过率(eGFR)、血肌酐、胱抑素C、白蛋白尿]相关性的临床证据，并回顾了二者相关性的可能机制，以期为CI的早期识别和预防提供帮助。

Reference

[1]虞倩,王蓓丽(综述),郭玮,等.肾小球滤过率的测定方法及其临床应用[J].2015,(7).
[2]王兴盛,何燕,刘光明.不同肾功能损伤患者认知功能差异分析[J].2016,(23).
[3]刘倩,李淑娟.认知功能障碍与其他系统性疾病的关系及治疗进展[J].2017,(15).
[4]中国痴呆与认知障碍诊治指南写作组,中国医师协会神经内科医师分会认知障碍疾病专业委员会.2018中国痴呆与认知障碍诊治指南（五）：轻度认知障碍的诊断与治疗[J].2018,(17).
[5]Shoko Kono,Hisashi Adachi,Mika Enomoto,etc.Impact of cystatin C and microalbuminuria on cognitive impairment in the population of community-dwelling Japanese[J].2017,265.
[6]Manjula, Kurella,Kristine, Yaffe,Michael G, Shlipak,etc.Chronic kidney disease and cognitive impairment in menopausal women.[J].2005,45(1).
[7]上海慢性肾脏病早发现及规范化诊治与示范项目专家组.慢性肾脏病筛查诊断及防治指南[J].2017,(1).
[8]Slinin, Yelena,Peters, Katherine W.,Ishani, Areef,etc.Cystatin C and Cognitive Impairment 10 Years Later in Older Women[J].2015,70A(6).
[9]Kielstein, Heike,Suntharalingam, Mayuren,Perthel, Ronny,etc.Role of the endogenous nitric oxide inhibitor asymmetric dimethylarginine (ADMA) and brain-derived neurotrophic factor (BDNF) in depression and behavioural changes: clinical and preclinical data in chronic kidney disease[J].2015,30(10).
[10]Sacre, Julian W.,Magliano, Dianna J.,Zimmet, Paul Z.,etc.Associations of Chronic Kidney Disease Markers with Cognitive Function: A 12-Year Follow-Up Study[J].2019,70(Suppl.1).
[11]Yagita, Yoshiki,Okazaki, Shuhei,Furukado, Shigetaka,etc.Chronic kidney disease is associated with dementia independent of cerebral small-vessel disease[J].2014,82(12).
[12]Unruh,M.L.,KurellaTamura,M.,Nissenson,A.R.,etc.Effect of more frequent hemodialysis on cognitive function in the frequent hemodialysis network trials[J].2013,61(2).
[13]Jianwei,Dong,Xiaofen,Ma,Wuhong,Lin,etc.Aberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease.[J].2018,14.
[14]Jaya A,George,Verena,Gounden.Novel glomerular filtration markers.[J].2019,88.
[15]Higuchi, Masaya,Chen, Randi,Abbott, Robert D.,etc.Mid-Life Proteinuria and Late-Life Cognitive Function and Dementia in Elderly Men The Honolulu-Asia Aging Study[J].2015,29(3).
[16]Daniel Pereda,Ibrahim Al&#x2010,Osta,etc.Changes in presynaptic calcium signalling accompany age‐related deficits in hippocampal LTP and cognitive impairment[J].2019,18(5).
[17]McIntyre, Christopher W.,Goldsmith, David J..Ischemic brain injury in hemodialysis patients: which is more dangerous, hypertension or intradialytic hypotension?[J].2015,87(6).
[18]Sarnak MJ,Madero M,Gul A.Cognitive function in chronic kidney disease.[J].2008,21(1).
[19]Levey, Andrew S.,Eckfeldet, John H..Estimating Glomerular Filtration Rate Using Serum Creatinine[J].2017,63(6).
[20]Zhang, Shufan,Luo, Yufan,Dong, Zhiyuan,etc.Impact of periventricular hyperintensities and cystatin C on different cognitive domains in the population of non-demented elderly Chinese[J].2019,68.
[21]Wang, Han,Fang, Chenli,Cai, Lin,etc.Chronic kidney disease and cognitive impairment among the very old in China[J].2016,28(3).
[22]Choukroun,G.,Massy,Z.A.,Bugnicourt,J.-M.,etc.Cognitive disorders and dementia in CKD: The neglected kidney-brain axis[J].2013,24(3).
[23]Deckers, Kay,Camerino, Ileana,van Boxtel, Martin P. J.,etc.Dementia risk in renal dysfunction A systematic review and meta-analysis of prospective studies[J].2017,88(2).
[24]Howard G,Allman RM,Yaffe K,etc.Kidney function and cognitive impairment in US adults: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.[J].2008,52(2).
[25]De Deyn PP,Vanholder R,Eloot S.Guanidino compounds as uremic (neuro)toxins.[J].2009,22(4).
[26]Dimitriou Nikolaos G.,Karalexi Maria A.,Tousoulis Dimitrios,etc.Albuminuria in Association with Cognitive Function and Dementia: A Systematic Review and Meta-Analysis[J].2017,65(6).
[27]Cummings SR,Yaffe K,Ayonayon H,etc.Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study.[J].2005,16(7).
[28]Yi, Yin,Meng, Li,Chao, Li,etc.Reduced White Matter Integrity With Cognitive Impairments in End Stage Renal Disease.[J].2018,9(Spec ).
[29]Etgen Thorleif.Kidney disease as a determinant of cognitive decline and dementia[J].2015,7(1).
[30]Weiner, Daniel E.,Gaussoin, Sarah A.,Nord, John,etc.Cognitive Function and Kidney Disease: Baseline Data From the Systolic Blood Pressure Intervention Trial (SPRINT)[J].2017,70(3).
[31]Seliger SL,Siscovick DS,Stehman Breen CO,etc.Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study.[J].2004,15(7).
[32]Lv, Zhian,Gao, Jie,Wang, Li,etc.Uremia-caused changes of ghrelin system in hippocampus may be associated with impaired cognitive function of hippocampus[J].2016,48(5).
[33]Bickel H,Chonchol M,Poppert H,etc.Chronic kidney disease is associated with incident cognitive impairment in the elderly: the INVADE study.[J].2009,24(10).
[34]Shavit,L.,Mikeladze,I.,Torem,C.,etc.Mild hyponatremia is associated with functional and cognitive decline in chronic hemodialysis patients[J].2014,82(5).
[35]Lingning Huang,Liyong Yang,Peiwen Wu,etc.Low-grade albuminuria is associated with poor memory performance in the nondemented Chinese elderly with type 2 diabetes[J].2017,32(6).
[36]Kristine Yaffe,Manjula Kurella-Tamura,Lynn Ackerson,etc.Higher levels of cystatin C are associated with worse cognitive function in older adults with chronic kidney disease: the chronic renal insufficiency cohort cognitive study.[J].2014,62(9).
[37]Maite Alzamora,Elena López-Cancio,Guillem Pera,etc.Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factors.[J].2013,36(2).
[38]Fu,R.-G.,Wang,L.,Yao,G.-L.,etc.Chronic renal failure impacts the expression of ghrelin and its receptor in hypothalamus and hippocampus[J].2012,34(8).
[39]Kunhao, Bai,Yujing, Pan,Fanghong, Lu,etc.Kidney function and cognitive decline in an oldest-old Chinese population.[J].2017,12(Spec ).
[40]Martens, Remy J. H.,Kooman, Jeroen P.,Stehouwer, Coen D. A.,etc.Estimated GFR, Albuminuria, and Cognitive Performance: The Maastricht Study[J].2017,69(2).