Abstract： Objective:To investigate the effect of Recombinant human granulocyte macrophage colony stimulating factor(rhGM-CSF)adjuvant therapy on acute myeloid leukemia(AML)induced chemotherapy complicated with OM and its effect on wound healing time.Methods:A retrospective study was performed on 48 cases of patients with AML induced chemotherapy for OM patients who were admitted from January 2017 to January 2019, 25 males and 23 females, aged(39.5±5.18)years old, ranging from 22 to 55 years old.All patients were randomly divided into the compound chlorhexidine group and rhGM-CSF group, with 24 cases in each group.Patients in the compound chlorhexidine group were treated with compound chlorhexidine gargle, and patients in combination with rhgm-csf group were treated alternately with rhGM-CSF gargle on the basis of compound chlorhexidine group.After 30 days of treatment, the effective rate of clinical treatment, degree of OM pain relief, OM healing time and occurrence of adverse reactions during treatment in the two groups were observed.Results:Joint rhGM-CSF OM total effective treatment group patients[87.5%(21/24)]above compound chlorhexidine group[62.5%(15/24)], OM pain relief rate[87.5%(21/24)]above compound chlorhexidine group[58.3%(14/24)], OM healing time short[(21.42 ± 3.26)days]from that of the group compound chlorhexidine[(23.59±4.16)days], the incidence of adverse reactions during the treatment[12.5%(3/24)]below compound chlorhexidine group[45.8%(11/24)], and the differences were statistically significant( P<0.05). Conclusion:For patients with OM complicated with AML induction chemotherapy, RhGM-CSf gargle combined with compound chlorhexidine gargle can improve the effective rate of treatment, effectively relieve pain, speed up OM wound healing, and reduce adverse reactions.It is worthy of clinical application.