Paper - WANFANG MED ONLINE

You Position: Home > Paper

microRNA在急性髓系白血病中的研究进展

( views:57, downloads:148 )

Author:: No author available

Journal Title:: China Clinical Practical Medicine

Issue:: 6

DOI:: 10.3760/cma.j.issn.1673-8799.2018.06.019

Key Word:: 白血病;MicroRNA;急性髓系白血病;肿瘤

Abstract： microRNA(miRNA)是一种在真核生物中被发现的小型的非编码RNA,其控制着许多参与造血干细胞的生成和分化以及肿瘤发生的基因表达.在人类急性髓系白血病( AML)中表达失调被发现.由于miRNA调控特定的基因转录对许多发育过程至关重要,因此,功能障碍的miRNA信号转导作用导致了AML. AML是一种高度异质性的疾病,其特征是骨髓前体细胞不能通过分化的前体细胞分化成成熟的血细胞,我们重点研究了一些研究小组报告在AML中的特定miRNA的表达模式和预后意义.

Reference

[1]Powell BL,Carter TH,Wetzler M,etc.FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.[J].2010,116(18).
[2]Sun,S.M.,Rockova,V.,Bullinger,L.,etc.The prognostic relevance of miR-212 expression with survival in cytogenetically and molecularly heterogeneous AML[J].2013,27(1).
[3]Diaz-Beya, M.,Brunet, S.,Nomdedeu, J.,etc.MicroRNA expression at diagnosis adds relevant prognostic information to molecular categorization in patients with intermediate-risk cytogenetic acute myeloid leukemia[J].2014,28(4).
[4]Xiaomeng, Huang,Sebastian, Schwind,Ramasamy, Santhanam,etc.Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia.[J].2016,(37).
[5]Wen, Xiang-mei,Zhang, Ting-juan,Wang, Yu-Xin,etc.Down-Regulation of miR-186 Correlates with Poor Survival in de novo Acute Myeloid Leukemia[J].2016,62(1).
[6]Khalife, J.,Radomska, H. S.,Santhanam, R.,etc.Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia[J].2015,29(10).
[7]Li,H.,Dai,S.,Zhen,T.,etc.Clinical and biological significance of miR-378a-3p and miR-378a-5p in colorectal cancer[J].2014,50(6).
[8]Huang, Kebin,Dong, Bingwei,Wang, Yueyue,etc.MicroRNA-519 enhances HL60 human acute myeloid leukemia cell line proliferation by reducing the expression level of RNA-binding protein human antigen R[J].2015,12(6).
[9]Huang,X.,Schwind,S.,Yu,B.,etc.Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: A novel therapeutic strategy in acute myeloid leukemia[J].2013,19(9).
[10]Morris, Valerie A.,Zhang, Ailin,Yang, Taimei,etc.MicroRNA-150 Expression Induces Myeloid Differentiation of Human Acute Leukemia Cells and Normal Hematopoietic Progenitors.[J].2013,8(9).
[11]P, Vargas Romero,S, Cialfi,R, Palermo,etc.The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBPα.[J].2015,29(12).
[12]Stefano Volinia,Jessica Kohlschmidt,Clara D Bloomfield,etc.Clinical Role of microRNAs in Cytogenetically Normal Acute Myeloid Leukemia: miR-155 Upregulation Independently Identifies High-Risk Patients.[J].2013,31(17).
[13].Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation[J].2012,125(2).
[14]Dan-Dan, Xu,Peng-Jun, Zhou,Ying, Wang,etc.miR-150 Suppresses the Proliferation and Tumorigenicity of Leukemia Stem Cells by Targeting the Nanog Signaling Pathway.[J].2016,(Spec ).
[15]Shaham,L.,Binder,V.,Gefen,N.,etc.MiR-125 in normal and malignant hematopoiesis[J].2012,26(9).
[16]Su, R.,Lin, H-S,Zhang, X-H,etc.MiR-181 family: regulators of myeloid differentiation and acute myeloid leukemia as well as potential therapeutic targets[J].2015,34(25).
[17]Roemhild J,Ovcharenko D,Neubauer A,etc.MicroRNA29a regulates the expression of the nuclear oncogene Ski.[J].2011,118(7).
[18]Yang, D. -Q.,Zhou, J. -D.,Wang, Y. -X.,etc.Low miR-34c expression is associated with poor outcome in de novo acute myeloid leukemia[J].2017,39(1).
[19]M Dahlhaus,C Roolf,S Ruck,etc.Expression and prognostic significance of hsa-miR-142-3p in acute leukemias.[J].2013,60(4).
[20]Li,Y.,Gao,L.,Luo,X.,etc.Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway[J].2013,121(3).
[21]Guang-jun Zhang,He Zhou,Hua-xu Xiao,etc.MiR-378 is an independent prognostic factor and inhibits cell growth and invasion in colorectal cancer.[J].2014,14(1).
[22]Tohda,S..NOTCH signaling roles in acute myeloid leukemia cell growth and interaction with other stemness-related signals[J].2014,34(11).
[23]Wallace, Jared A.,O'Connell, Ryan M..MicroRNAs and acute myeloid leukemia: therapeutic implications and emerging concepts[J].2017,130(11).
[24]Zheng, Guoguang,Tian, Chen,You, M. James,etc.MicroRNA-9 promotes proliferation of leukemia cells in adult CD34-positive acute myeloid leukemia with normal karyotype by downregulation of Hes1[J].2016,37(6).
[25]YI XIAO,TAORAN DENG,CHANGLIANG SU,etc.MicroRNA 217 inhibits cell proliferation and enhances chemosensitivity to doxorubicin in acute myeloid leukemia by targeting KRAS.[J].2017,13(6).
[26]Shi, Jinlong,Fu, Lin,Li, Yonghui,etc.Identification of let-7a-2-3p or/and miR-188-5p as prognostic biomarkers in cytogenetically normal acute myeloid leukemia.[J].2015,10(2).
[27]Jin, Bai,Aiping, Guo,Ze, Hong,etc.Upregulation of microRNA-100 predicts poor prognosis in patients with pediatric acute myeloid leukemia.[J].2012,5.
[28]Xi, Jiang,Chao, Hu,Stephen, Arnovitz,etc.miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia.[J].2016.
[29]Lal, Kumar,Yang, Frank F.,Chen, Jianjun,etc.The pathological role and prognostic impact of miR-181 in acute myeloid leukemia[J].2015,208(5).
[30]Ufkin,M.L.,Peterson,S.,Yang,X.,etc.MiR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia[J].2014,38(3).
[31]Han YC,Park CY,Bhagat.microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia.[J].2010,207(3).
[32]Haruna, Yamamoto,Jun, Lu,Shigeyoshi, Oba,etc.miR-133 regulates Evi1 expression in AML cells as a potential therapeutic target.[J].2016.
[33]Hussein, Fayyad-Kazan,Nizar, Bitar,Mehdi, Najar,etc.Circulating miR-150 and miR-342 in plasma are novel potential biomarkers for acute myeloid leukemia.[J].2013,11.