Abstract： Objective To investigate the prediction value of liver cancer different staging criteria on liver cancer resection. Methods Clinical data of 218 cases with advanced liver cancer in four hospitals were selected. All patients were scored by CS、CLIP、TNM staging and OKUDA. Evaluated this four staging systems on survival prediction value of 6 month advanced liver cancer. COX proportional hazard model was used to eliminate likelihood estimator in order to judge which staging criteria had better prognosis prediction. Results Follow-up period of 218 cases was 2-36 month, average follow-up time was (22.34±5.89)month, three-year survival rate was 33.94%, median survival time was 25.38 month. Of the four staging methods, degree of distinction was better TNM staging、OKUDA staging criteria. At the mean time,homogeneity,discrimination power,gradient singularity of TNM staging and OKUDA staging criteria all had higher contributed value. Conclusions Application of TNM staging, OKUDA on liver cancer resection have better survival prediction value.