Abstract： Objective To discuss the importance and seeurity of renal biopsy with automatic biopsy gun. Methods 132 patients were performed renal biopsy in our hospital from january, 2004 to september, 2007. The eomplieation ineidenee and related factors were analysed in the eases. Results The suecessful rate for getting sample was 96. 2%. All the patients undergoing renal biopsy got identified pathological diagnosis. The incidence of mild complications was 8. 33%, the incidence of severe complications was 1.52%. The incidence had no relation with sex, age, puncturing times, or neddle types. The incidence of severe complications had some relation with preoperative and postoperative medication and management. Conclusion With good preoperative preparation, strict indications for it,and resonable preoperative and postoperative medication, renal biopsy was a safe, useful, and important diagnostic method.