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血表皮生长因子及受体对黄体期子宫内膜的作用
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- Author:
- No author available
- Journal Title:
- CHINA CLINICAL PRACTICAL MEDICINE
- Issue:
- 12
- DOI:
- No doi available
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Abstract： 目的 了解在黄体功能正常及黄体功能不全的患者中,血表皮生长因子(EGF)水平及子宫内膜表皮生长因子受体EGFR-mRNA的表达,进而探讨其对分泌期子宫内膜的作用.方法 用RTPCR检测20例黄体功能正常及40例黄体功能不全患者宫内膜EFGR-mRNA的表达情况,结合子官内膜组织学及血清EGF水平,进行分析.结果 血清EGF在黄体功能正常组水平(7.31±2.05 ng/ml)显著高于黄体功能不全组(4.23±1.90 ng/ml),EGFR-mRNA在黄体功能正常妇女分泌期宫内膜的表达(RI值0.523±0.024)亦显著高于黄体功能不全妇女(RI值0.311±0.022).结论 EGF及EGFR在分泌期对宫内膜细胞的生长和分化起着十分重要的作用.
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