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人类肌肉再生过程一种关键机制揭开
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Biomedical Engineering
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1674-1927.2018.06.005
- Key Word:
- No keyword available
Abstract： 《科技日报》电,英国《自然》杂志近日在线发表的一篇医学论文称,蛋白质TDP?43会在正常的肌肉生长和再生过程中积聚,并发挥功能性作用.TDP?43常常和肌萎缩性脊髓侧索硬化症(ALS)等神经肌肉疾病关联起来,而且被认为具有致病性.科学家认为,疾病中肌肉再生的增加可能会导致这种蛋白质的有害积聚.研究显示,TDP?43蛋白聚集体会在患有神经肌肉疾病(如包涵体肌病)的患者的骨骼肌中积聚.降低TDP?43水平会导致小鼠和果蝇的年龄相关性肌无力,这表明TDP?43可能在肌肉形成中发挥着功能性作用.此次,美国科罗拉多大学博尔德分校科学家罗伊·派克、布莱德·奥尔文及其同事,研究了TDP?43在正常的哺乳动物骨骼肌形成期间的功能.他们发现,TDP?43在小鼠肌肉细胞中含量丰富,并且在骨骼肌细胞形成过程中会增加.遗传性消耗TDP?43可阻止细胞生长并导致细胞死亡,这表明该蛋白质在肌肉再生中发挥着重要的功能性作用.
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