Abstract： Objective To quantitatively measure the white matter hyperintensities (WMHs) volume in various parts of the brain in patients with different types of dementia,and to analyze the correlation between WMHs volume and cognitive function.Methods The clinical data and MRI findings of patients with Alzheimer's disease (AD,n=17),mixed dementia (MD,n=12) and vascular dementia (VD,n=15) admitted to Department of Neurology,Guangzhou First Municipal People' s Hospital,Guangzhou Medical University from 2008 to 2012 were collected.FLAIR images from the 3 groups of patients were analyzed by using computer-aided detection techniques,and the WMHs volume at paraventricular,supraventricular and infraventricular sections were measured.Individual and total WMHs volumes were compared within each group and among 3 groups,and were studied for their correlations with the scores of mini-mental state examination (MMSE).Results There was a statistical difference in the MMSE score among 3 groups (F=9.715,P=0.000).The MMSE score of MD group was obviously lower than that of VD group (16.4±7.1 vs 19.3 ± 4.3,P＜0.05).The paraventricular WMHs volume was greater compared with the infraventricular WMHs volume in all the 3 groups (all P＜0.05).In VD group,particularly,the WMHs volume was greatest at the paraventricular section,followed by supraventricular and infraventricular sections (both P＜0.05).Nosignificant difference was found in the total volume of WMHs in the patients of 3 groups (F=0.838,P＞0.05).The WMHs volume at infraventricular section in MD patients was greater than that in AD patients (P＜0.05).A negative correlation was found between the total WMHs volume and MMSE scores in the AD patients (r=-0.360,P=0.004).Conclusions WMHs volume at different sections of the brain in patients may be successfully acquired by using automated WMHs measurement techniques.The distribution of WMHs at different sections varies among patients with different types of dementia.