The molecular mechanisms of pain on the basis of systemic biology
- Author:
- No author available
- Journal Title:
- Chinese Journal of Biomedical Engineering
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1674-1927.2012.06.017
- Key Word:
- 疼痛;蛋白;衔接蛋白质类,信号转导;支持向量机;Pain;Egg white;Adaptor proteins,signal transducing;Support vector machine
Abstract： Objective To study the mechanisms of pain based on systemic biology.Methods By applying the support vector machine (SVM) algorithm,protein-protein interactions (PPI) networks of pain were established in combination of the information available on Gene Ontology and KEGG databases for further deduction of the molecular pathways of pain in humans.Results Seven signaling pathways,including MAPK,LTD and LTP signaling pathways,were found to be involved in the signal networks of pain.Calcium,Ras,PLCγ,PLCβ,PKA,IP3,CaM and PKC played pivotal roles in multiple signal transduction pathway cascades.Conclusion Central sensitization plays a critical role in the development of chronic pain due to long-term depression.
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