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凋亡素选择性抗肿瘤的分子机制

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Author:: No author available

Journal Title:: Chinese Journal of Biomedical Engineering

Issue:: 2

DOI:: 10.3760/cma.j.issn.1674-1927.2012.02.018

Key Word:: No keyword available

Abstract：凋亡素(apoptin)是一种来源于鸡贫血病毒(chicken anemia virus,CAV)的小分子量蛋白.CAV是一种无囊膜的DNA病毒,其基因组为2300 bp的单链环状DNA分子,含有3个完全或部分重叠的开放读码框,分别编码3个蛋白质:VP1、VP2和VP3[1].VP1为主要的衣壳蛋白,相对分子质量51 600.VP2为非结构蛋白,相对分子质量24 000,其具有双重性质的磷酸酶活性并且主要与VP1相互作用.VP1与VP2为CAV复制所必需[2].VP3亦称为凋亡素,相对分子质量13 600,能选择性诱导多种肿瘤细胞凋亡,如骨肉瘤、肝癌、黑色素瘤、肺癌、前列腺癌等,而不杀伤正常细胞[1,3-5].

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