Paper - WANFANG MED ONLINE

You Position: Home > Paper

非小细胞肺癌预后基因及其单核苷酸多态性的研究进展

( views:155, downloads:13 )

Author:: No author available

Journal Title:: Chinese Journal of Biomedical Engineering

Issue:: 6

DOI:: 10.3760/cma.j.issn.1674-1927.2011.06.017

Key Word:: No keyword available

Abstract：肺癌是人类最常见的恶性肿瘤之一,主要分为小细胞癌(SCLC)及非小细胞癌(NSCLC)两大类,其中NSCLC约占80％～ 85％.2008年肺癌在全世界的发病率(17％)和病死率(23％)已跃居所有恶性肿瘤榜首[1].2010年美国新发肺癌有22万,超过15万人死于肺癌[2].在我国所有恶性肿瘤中肺癌的病死率增长速度最快[3].对于肺癌的发生、发展及转归,各个地区、不同人种有很大差异,提示遗传或变异可能是其中的原因之一.人体中99.9％的基因在不同个体中是一样的,仅存在0.1％的差异,这些差异大部分是基因单核苷酸多态性(SNP).目前,随着肺癌SNP的单体型图谱构建完成和高通量基因分型技术的发展,肺癌遗传个体化研究成为了可能,这为将来肺癌患者的个体化预防、治疗提供了技术条件.

Reference

[1]邹小农.中国肺癌流行病学[J].2007,(12).
[2]Budihardjo,I,Oliver,H,Lutter,M,etc.Biochemical pathways of caspase activation during apoptosis.[J].1999,15.
[3]Maouche K,Burlet H,Totobenazara JL,etc.Expression of nicotinic receptors in normal and tumoral pulmonary neuroendocrine cells (PNEC).[J].2008,204(12).
[4]Tanoue LT,Detterbeck FC,Boffa DJ.The new lung cancer staging system.[J].2009,136(1).
[5].Global cancer statistics[J].2011,61(2).
[6]Cortes RY,Schlichting NA,Improgo MR,etc.ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus.[J].2010,8(2).
[7]Jiang Q,Pantuck A,Belldegrun A,etc.Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites.[J].2008,17(11).
[8]Nguyen T,Osthus RC,Zeller KI,etc.The c-Myc target gene network.[J].2006,16(4).
[9]Marc Campayo,Nuria Viñolas,Alfons Navarro,etc.Single Nucleotide Polymorphisms in Tobacco Metabolism and DNA Repair Genes and Prognosis in Resected Non-Small-Cell Lung Cancer[J].2011,167(1).
[10]Sotelo, J,Esposito, D,Duhagon, MA,etc.Long-range enhancers on 8q24 regulate c-Myc[J].2010,107(7).
[11]Sasaki, H.,Hikosaka, Y.,Okuda, K.,etc.CHRNA5 Gene D398N Polymorphism in Japanese Lung Adenocarcinoma[J].2010,162(1).
[12]Park JY,Kim KM,Jung TH,etc.Identification of polymorphisms in the Caspase-3 gene and their association with lung cancer risk.[J].2008,47(5).
[13]Donald W. Nicholson,Nancy A. Thornberry.Caspases: killer proteases[J].1997,22(8).
[14].A variant associated with nicotine dependence, lung cancer and peripheral arterial disease[J].2008,452(TN.7187).
[15]Boyce M,Degterev A,Yuan J.A decade of caspases.[J].2003,22(53).
[16]Kumar S.Caspase function in programmed cell death.[J].2007,14(1).
[17]Mitchell M,Lindahl T,Wood RD.Human DNA repair genes, 2005.[J].2005,577(1).
[18]Choi JE,Lee W,Yoo SS.Polymorphisms in the CASPASE genes and survival in patients with early-stage non-small-cell lung cancer.[J].2009,27(34).
[19]Kim M,Kang HG,Lee SY,etc.Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.[J].2010,101(11).
[20]Kohno T,Shiraishi K,Kato M,etc.MYC amplification as a prognostic marker of early-stage lung adenocarcinoma identified by whole genome copy number analysis.[J].2011,17(6).
[21]Christopher M, Booth,Frances A, Shepherd.Adjuvant chemotherapy for resected non-small cell lung cancer.[J].2006,1.
[22]Park JY,Park JM,Jang JS,etc.Caspase 9 promoter polymorphisms and risk of primary lung cancer.[J].2006,15(12).
[23]Liao M,Lu S,Li Z,etc.Association of the CHRNA3 locus with lung cancer risk and prognosis in Chinese Han population.[J].2010,5(5).
[24]Victoria H. Cowling,Michael D. Cole.Myc Regulation of mRNA Cap Methylation[J].2010,1(6).
[25]Mollberg N,Surati M,Demchuk C,etc.Mind-mapping for lung cancer: towards a personalized therapeutics approach.[J].2011,28(3).
[26]Spitz MR,Lin J,Wu X,etc.The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer.[J].2008,100(21).
[27]Penn LZ,Meyer N.Reflecting on 25 years with MYC.[J].2008,8(12).
[28]Kanaki M,Kalikaki A,Souglakos J,etc.DNA repair gene polymorphisms predict favorable clinical outcome in advanced non-small-cell lung cancer.[J].2009,10(2).