Meta-analysis of mild hypothermia therapy in cardiopulmonary resuscitation after cardiac arrest
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1674-1927.2009.02.013
- Key Word:
- 心肺复苏术;心脏停博;血液循环;低温;生存率;Cardiopulmonary resuscitation;Heart arrest;Blood circulation;Hypothermia;Survival rate
Abstract： Objective To evaluate the efficacy and safety of cardiopulmonary resuscitation (CPR) with mild hypothermia therapy for restoration of spontaneous circulation (ROSC) after cardiac arrest (CA). Methods The data about the efficacy and/or safety of CPR with mild hypothermia therapy after ROSC were chosen from PubMed Data Base (from Jan 1966 to Aug 2008), and domestic literature data were chosen from CNKI (from Jan 1994 to Aug 2008)and Wangfang Data Base (from Jan 1994 to Aug 2008)by computer retrieval. Meta-analysis was applied to evaluate the result. In all the literature data conformed to inclusive criteria, mild hypothermia therapy was compared with normothermia. Results Seven clinical research papers were enrolled in Mata- analyzsis. Compared with normothermia group, the OR of the survival rate to discharged patients in mild hypothermia therapy group was 2.29 (95% CI 1.75-2.98, P<0.01 ), the OR of discharge and long-term cerebral functions were 2.04 (95% CI 1.55-2.67, P<0.01 ) and 2.17 (95% CI 1.44-3.27, P<0.01 ) , respectively. The adverse reactions related to the therapy were not significantly different between two groups. Conclusions CPR with the mild hypothermia therapy for ROSC is safe and effective. It can improve discharge and long-term cerebral functions, and increase the survival rate of discharged patients.
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