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The Study of Distribution and Ingestion of 99mTc-Citrate in the Osteoarthritis' Animal Model
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- Author:
- No author available
- Journal Title:
- JOURNAL OF MODERN CLINICAL MEDICAL BIOENGINEERING
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1674-1927.2002.05.030
- Key Word:
- 骨关节炎;99m锝-枸橼酸;动物模型;摄取;分布
Abstract： 目的利用骨关节炎症动物模型观察99mTc-枸橼酸的生物分布和在骨关节炎症区域的代谢特点. 方法在制作骨关节炎症动物模型的基础上,经在体显像及其感兴趣区技术计算器官和炎症关节的放射性活度的变化,同时也利用动物模型离体的测量器官或组织的百分注射量,分析99mTc-枸橼酸在各器官和骨关节炎症区域的代谢特点. 结果 99mTc-枸橼酸的蛋白结合率为17.01±0.75%,骨关节炎症区域对99mTc-枸橼酸有较高的摄取,骨关节炎症的患/健比值出现在注射示踪剂后的30分钟到1小时之间:在体显像患/健比值分别为4.120±0.552和3.150±0.587;百分注射量靶/非靶比值分别为3.279±0.463和3.899±0.125.99mTc-枸橼酸主要经泌尿系统排出,少量经肝脏-肠道系统排出. 结论 99mTc-枸橼酸有较低的蛋白结合率,是急性骨关节炎症良好的显像剂,其最佳显像时间为注射99mTc-枸橼酸后的1小时.
- [1]J G, McAfee,G, Subramanian,G, Gagne.Technique of leukocyte harvesting and labeling: problems and perspectives.[J].1984,14.
- [2]MELTEM Ç,A&Gbreve,LAR,etc.The Value of Tc-99m Citrate Scintigraphy in Chronic OsteomyelitisAn Indicator of the Involved Bone[J].1995,20(8).
- [3]J P, Lavender,J, Lowe,J R, Barker,etc.Gallium 67 citrate scanning in neoplastic and inflammatory lesions.[J].1971,44.
- [4]Rubin, R.H.,Fischman, A.J..111 In-labeled nonspecific immunoglobulin scanning in the detection of focal infection.[J].1989,321(14).
- [5]M L, Thakur,R E, Coleman,M J, Welch.Indium-111-labeled leukocytes for the localization of abscesses: preparation, analysis, tissue distribution, and comparison with gallium-67 citrate in dogs.[J].1977,89.
- [6]M T, Ercan,T, Aras,E, Unlenen,etc.99mTc-citrate versus 67Ga-citrate for the scintigraphic visualization of inflammatory lesions.[J].1993,20(7).