Abstract： Objective:To analyze the associations of forced expiratory volume in the first second in percent predicted values ( FEV 1%pred), St George′s respiratory questionnaire (SGRQ), modified Medical Research Council (mMRC) and COPD Assessment Test (CAT) Scores in chronic obstructive pulmonary disease (COPD) patients. Methods:This was a prospective study.From January 2019 to January 2020, a total of 68 patients with COPD were selected in Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital and Lian Yang Community Health Service Center.These patients were followed up at the scheduled time point.The results of FEV 1%pred, SGRQ questionnaire, mMRC score and CAT score were recorded.The patients were divided into group A (mild group) with 49 cases and group B (severe group) with 19 cases.This study analyzed the effects of time changes on the three scoring systems and FEV 1%pred.The correlation between the three scoring systems and FEV 1%pred was statistically analyzed by Pearson correlation analysis. Results:There were no significant difference in FEV 1%pred, SGRQ, mMRC and CAT scores with groups·time points (all P>0.05), but there were significant difference between the two groups or time points (all P<0.01), except mMRC ( P>0.05). Overall, there were significant differences in FEV 1%pred, mMRC and CAT over time (all P<0.05), but there was no significant difference in SGRQ over time ( P>0.05). There was no significant difference between the follow-up data of FEV 1%pred, SGRQ, mMRC, CAT with the data of enrollment time (all P>0.05), except FEV 1%pred 10th and 13th, CAT 7th month.SGRQ was negatively correlated with FEV 1%pred at all time points (all P<0.01). FEV 1%pred was negatively correlated with mMRC and CAT at 1st and 13th month (all P<0.05), and FEV 1%pred was negatively correlated with CAT at 4th, 7th and 13th month (all P<0.05). Conclusions:CAT score and SGRQ score could reflect the changes of lung function levels of patients.In actual clinical work, the applicability of CAT score should be more applicable than SGRQ score.