Abstract： Objective:To explore the expression and correlation of thrombus markers and inflammatory markers in chronic obstructive pulmonary disease (COPD).Methods:A prospective study was performed in 96 COPD patients (COPD group) and 62 COPD patients with pulmonary hypertension (PAH)(COPD+ PAH group) from Longyan First Hospital, Affiliated to Fujian Medical University from October 2017 to February 2020.Sixty healthy subjects were selected as the healthy control group during the same period.The three groups were detected in blood coagulation indexes: prothrombin time (PT), activated partial prothrombin time (APTT), fibrinogen (Fib), D-dimer and thrombus markers tissue factor (TF), tissue factor pathway inhibitor 1 (TFPI-1); inflammation markers: tumor necrosis factor alpha (TNF-α), interleukin 8 (IL-8), C-reactive protein (CRP) level.The correlation between TF, TFPI-1, TF/TFPI and TNF-α, IL-8, CRP and pulmonary artery pressure (PASP) were analyzed.Results:COPD group and COPD+ PAH group showed higher Fib, D-dimer, TF, TFPI-1, TNF-α, IL-8 and CRP levels than the control group.COPD+ PAH group showed higher Fib, D-dimer, TF, TF/TFPI, TNF-α, IL-8 and CRP levels than COPD group.But, COPD+ PAH group experienced lower TFPI-1 than COPD group.TF/TFPI level in COPD+ PAH group was higher than that in the control group (all P<0.05). Correlation analysis showed that blood TNF-α, IL-8, CRP , PASP in all COPD patients correlated positively with TF ( r=0.830, 0.870, 0.785, 0.881, all P<0.05), and positively correlated with TF/TFPI ( r=0.771, 0.815, 0.674, 0.852, all P<0.05). Blood TNF-α, IL-8, CRP and PASP positively correlated ( r=0.816, 0.865, 0.692, all P<0.05). The TNF-α, IL-8, CRP, PASP were positively correlated with TFPI-1 in COPD group ( r=0.351, 0.541, 0.532, 0.374, all P<0.05). But, TNF-α, IL-8, CRP, PASP and TFPI- 1 were negatively correlated in COPD+ PAH group ( r=-0.389, -0.246, -0.464, -0.467, all P<0.05). Conclusions:Thromboembolism markers TF, TFPI-1 and inflammation markers TNF-α, IL-8, CRP had good correlation.COPD patients with PAH showed higher inflammation reactions, and coagulation imbalance, which played an important role in the occurrence and development of COPD and related PAH.