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Immunoregulatory mechanism of non-cystic fibrosis bronchiectasis

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Author:: No author available

Journal Title:: International Journal of Respiration

Issue:: 4

DOI:: 10.3760/cma.j.issn.1673-436X.2014.04.016

Key Word:: 支气管扩张症;免疫调节;白细胞;细胞因子;Bronchiectasis;Immunoregulation;Leukocyte;Cytokine

Abstract： Bronchiectasis is one of chronic inflammatory bronchial diseases,with the pathological presentation of one or more bronchial permanent dilation,Non-cystic fibrosis bronchiectasis is usually associated with recurrent infections,immunodeficiency or autoimmune diseases,and a quite portion is specific.The vicious cycle of bacterial colonization,airway inflammation,and airway structural damage results in bronchiectasis.Airway inflammation is the key of the cycle,therefore,the studies of immunoregulatory mechanism of airway inflammation are important,which can guide the research and development of drugs in bronchiectasis.This review focuses on molecular and cellular immunoregulatory mechanism associated with the pathogenesis of bronchiectasis,and discusses the mechanism of bacterial chronic colonization.Drug research and development associated with immunoregulation in bronchiectasis is also discussed.

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