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New insights of prophylactic cranial irradiation associated neurotoxicity in treatment of small cell lung cancer
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- Author:
- No author available
- Journal Title:
- International Journal of Respiration
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1673-436X.2014.04.009
- Key Word:
- 小细胞肺癌;预防性脑照射;神经毒性;Small cell lung cancer;Prophylactic cranial irradiation;Neurotoxicity
Abstract： Small cell lung cancer is a relatively high malignant tumor among lung cancers,and the high incidence of brain metastases has been paid great attention for a long time.To address this situation,prophylactic cranial irradiation (PCI) has been proposed and applied in the treatment of small cell lung cancer for many years.However,neurotoxicity after radiotherapy has been greatly controversial.Recent[y,a number of scholars argue that neurotoxic symptoms of PCI are caused by a variety of factors.Considering the exact effect of PCI on improving patients' survival time,the exact value of PCI in clinical application should be affirmed.
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