Paper - WANFANG MED ONLINE

You Position: Home > Paper

Role of NF-κB signaling pathway in lung cancer

( views:195, downloads:68 )

Author:: No author available

Journal Title:: International Journal of Respiration

Issue:: 18

DOI:: 10.3760/cma.j.issn.1673-436X.2013.018.011

Key Word:: 核因子κB;抑制性κB;IκB激酶;肺癌;Nuclear factor-κB;Inhibitor-κB;IκB kinase;Lung cancer

Abstract： Nuclear factor-κB (NF-κB) is a nuclear transcription factor that regulates expression of diverse genes.Its activation disproportion is not only involved in a variety of inflammatory diseases,but also plays an important role in the development,progress,metastasis,and treatment of lung cancer.Recently,some studies have found that NF-κB may be a target for anti-cancer drugs,providing a new idea for the treatment of lung cancer and other malignant tumors.

Reference

[1]吴春婷,朱光发.核因子κB信号通路与急性肺损伤关系的研究进展[J].2008,(20).
[2]巩翠珂,张薇.吸入糖皮质激素对肺癌的预防作用机制进展[J].2011,(21).
[3]颜临丽,李娜萍.TGF-βRⅡ、NF-κB在肺癌中的表达及肿瘤相关性巨噬细胞计数与肺癌临床病理特征的关系[J].2010,(5).
[4]Chariot, Alain.The NF-kappa B-independent functions of IKK subunits in immunity and cancer[J].2009,19(8).
[5]Arora H,Park WY,Qureshi R,etc.miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFkappaB1.[J].2011,43(5).
[6]Chariot A,Bours V,Viatour P,etc.Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation[J].2005,30(1).
[7]Murakami A,Aggarwal BB,Takada Y.Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion.[J].2005,24(46).
[8]Lin Y,Bai L,Chen.The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy.[J].2010,14(1).
[9]Brody JS,Spira A.State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer.[J].2006,3(6).
[10]Lee JH,Koo TH,Yoon H,etc.Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid.[J].2006,72(10).
[11]Sergei I. Grivennikov,Florian R. Greten,Michael Karin.Immunity, Inflammation, and Cancer[J].2010,140(6).
[12]Lorimer EL,Li R,Zhi H,etc.SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma.[J].2008,283(2).
[13]Karin M.NF-kappaB and cancer: mechanisms and targets.[J].2006,45(6).
[14]Lin Y,Chen W,Li Z,etc.NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target.[J].2011,16(P803).
[15]Stathopoulos GT,Sherrill TP,Cheng DS,etc.Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis.[J].2007,104(47).
[16]Sanda T,Okamoto T,Asamitsu K.NF-kappa B signaling and carcinogenesis.[J].2007,13(5).
[17]Huber MA,Beug H,Wirth T.Epithelial-mesenchymal transition: NF-kappaB takes center stage.[J].2004,3(12).
[18]Schoonbroodt S,Ferreira V,Best Belpomme-M,etc.Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of I kappa B alpha in NF-kappa B activation by an oxidative stress.[J].2000,164(8).
[19]Lotan R,Cheng Y.Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor.[J].1998,273(52).
[20]Forman S,Kujawski M,Pardoll DM,etc.Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.[J].2009,15(4).
[21]Yagita H,Karin M,Hsu LC,etc.Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression.[J].2004,6(3).
[22]Hoffmann A,Natoli G,Ghosh G.Transcriptional regulation via the NF-kappaB signaling module.[J].2006,25(51).
[23]Etienne, Meylan,Alison L, Dooley,David M, Feldser,etc.Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma.[J].2009,462(7269).
[24]Rhoads MG,Pacelli,Kandarian SC.Expression of NF-kappaB and IkappaB proteins in skeletal muscle of gastric cancer patients.[J].2010,46(1).
[25]Jiong, Deng,Junya, Fujimoto,Xiao-Feng, Ye,etc.Knockout of the tumor suppressor gene Gprc5a in mice leads to NF-kappaB activation in airway epithelium and promotes lung inflammation and tumorigenesis.[J].2010,3(4).
[26]Hsin-Yu Fang,Greten, Florian R..Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors.[J].2011,3(2).
[27]薛凤麟,张旋,王殿华.核因子-κB与肺疾病研究进展[J].2009,(3).
[28]Takada Y,Kobayashi Y,Aggarwal BB.Evodiamine abolishes constitutive and inducible NF-kappa B activation by inhibiting I kappa B alpha kinase activation, thereby suppressing NF-kappa B-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting inva[J].2005,280(17).
[29]Tao Q,Lee JJ,Mao L,etc.Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene.[J].2007,99(22).
[30]Maier HJ,Schmidt Strassburger U,Huber MA,etc.NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells.[J].2010,295(2).
[31]Yasunori Saitoh,Vicente Javier Martínez Bruyn,Shin Uota,etc.Overexpression of NF-κB inducing kinase underlies constitutive NF-κB activation in lung cancer cells[J].2010,70(3).