Myeloid-derived suppressor cells in patients with active tuberculosis
- Author:
- No author available
- Journal Title:
- International Journal of Respiration
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1673-436X.2012.006.002
- Key Word:
- 肺结核;髓系抑制性细胞;流式细胞术;Tuberculosis;Myeloid-derived suppressor cells;Flow cytometry
Abstract： Objective To investigate the production and frequencies of myeloid-derived suppressor cells (MDSCs) in patients with pulmonary tuberculosis,individuals with latent infection and healthy controls.Methods Peripheral blood from 78 pulmonary tuberculosis patients,30 latent infection individuals and 66 healthy controls were stained with fluorescence-labeled CD14,HLA-DR,CD11b and CD33 antibodies,and analyzed with flow cytometry.Results Patients with active pulmonary tuberculosis had significantly elevated frequencies of CD14- HLA-DR-CD33+ CD11b(h)igh MDSCs compared with individuals with latent infection ( P =0.0238) and healthy controls ( P ＜ 0.001). However,the frequency of CD14+ HLA-DR- MDSCs did not show significant difference among the three groups.Serum transforming growth factor-β1 level in tuberculosis patients was significantly higher than that in healthy controls ( P ＜0.05).Conclusions In active pulmonary tuberculosis patients,the frequencies of CD14- HLA-DR- CD33+ CD11bhigh MDSCs increase significantly and might play an important role in tuberculosis development through suppression of anti-tuberculosis immune responses.
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