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Research progress of vascular endothelial growth factor in lung cancer

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Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF RESPIRATION

Issue:: 4

DOI:: 10.3760/cma.j.issn.1673-436X.2011.004.015

Key Word:: 血管内皮生长因子;肺癌;自分泌;上游基因;Vascular endothelial growth factor;Lung cancer;Autocrine;Upstream gene

Abstract： Vascular endothelial growth factor (VEGF) is found as the most important stimulating factor in the blood vessels. VEGF expression in malignant tumors is significantly higher than that in normal tissues. It promotes tumor growth and metastasis by stimulating the formation of tumor blood vessels and lymphatic vessels. Therefore, targeted therapy against VEGF has been research focus recently. The researches about autocrine mechanism and upstream regulatory genes of VEGF provide more new tools for targeted therapy of lung cancer through VEGF.

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