Abstract： Bim is a proapoptotic BH3-domain-only member of the Bcl-2 family,which is widely distributed in muhicellular organisms and has distinct potency in promoting death,oncogenesis,the homeostasis of hematopoietic cell and autoimmunity.As a strong mediator of apoptosis,its expression and functional regulation are various in different kinds of cells.The induction of Bim is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.Bim also plays an important role in the mechanisms underlying glucocorticoid resistance in leukemic cells.And using the expression vector of Bim to transfect tumor cells may become a new way in tumor gene therapy.