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Detection and clinical significance of micrometastasis in patients with lung cancer

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Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF RESPIRATION

Issue:: 16

DOI:: 10.3760/cma.j.issn.1673-436X.2007.16.017

Key Word:: 微转移;非小细胞肺癌

Abstract：微转移是手术后非小细胞肺癌复发的关键因素.常规方法和技术难以发现这些隐匿性的癌细胞,运用分子生物学等敏感技术可有效发现肺癌患者淋巴结、骨髓、外周血等组织中的微转移.早期诊断和发现微转移可为确定肺癌分子分期,制定多学科综合治疗方案,评价治疗效果以及判断预后提供依据.本文对近年来国内外学者在检测肺癌微转移方面的研究进展作一综述.

Reference

[1]陈乾坤,丁嘉安,朱余明.肺癌根治术后支气管残端微转移灶检测的预后价值[J].2005,(2).
[2]张贺龙,王文亮.检测外周血中p53基因突变诊断肺癌微转移的临床意义[J].2002,(1).
[3]周清华,刘伦旭,王允,等.非小细胞肺癌患者淋巴结、外周血及骨髓微转移分子诊断在肺癌外科治疗中的作用[J].2001,(6).
[4]黄进肃,董强刚,包国良,等.血液中微转移癌细胞对非小细胞肺癌预后的影响[J].2004,(5).
[5]K, Pantel,J, Izbicki,B, Passlick,etc.Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases.[J].1996,347.
[6]J, Brabender,K D, Danenberg,R, Metzger,etc.Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival.[J].2001,7(7).
[7]C T, Salerno,S, Frizelle,G A, Niehans,etc.Detection of occult micrometastases in non-small cell lung carcinoma by reverse transcriptase-polymerase chain reaction.[J].1998,113(6).
[8]J. Buhr,K.H. Berghäuser,S. Gonner,etc.The prognostic significance of tumor cell detection in intraoperative pleural lavage and lung tissue cultures for patients with lung cancer[J].1997,113(4).
[9]Ito M,Minamiya Y,Kawai H,etc.Intraoperative detection of lymph node micrometastasis with flow cytometry in non-small cell lung cancer.[J].2005,130(3).
[10]McGuckin MA,Cummings MC,Walsh MD,etc.Occult axillary node metastases in breast cancer: their detection and prognostic significance[J].1996.
[11]A.G Nicholson,A.N.J Graham,F Pezzella,etc.Does the use of immunohistochemistry to identify micrometastases provide useful information in the staging of node-negative non-small cell lung carcinomas?[J].1997,18(3).
[12]Wu J,Nonomura A,Oda M,etc.Can tumor size be a guide for limited surgical intervention in patients with peripheral non-small cell lung cancer? Assessment from the point of view of nodal micrometastasis.[J].2001,122(5).
[13]M, Okada,N, Tsubota,M, Yoshimura,etc.Role of pleural lavage cytology before resection for primary lung carcinoma.[J].1999,229.
[14]Nagi S, El Saghir,Ihab I, Elhajj,Fady B, Geara,etc.Trauma-associated growth of suspected dormant micrometastasis.[J].2005,5.
[15]Maddaus MA,Gruessner AC,D'Cunha J,etc.Expression profiling of non-small cell lung carcinoma identifies metastatic genotypes based on lymph node tumor burden.[J].2004,127(5).
[16]Kazuhito Dobashi,Kenji Sugio,Toshihiro Osaki,etc.Micrometastatic p53-positive cells in the lymph nodes of non-small-cell lung cancer: Prognostic significance[J].1997,114(3).
[17]B, Naume,E, Borgen,K, Beiske,etc.Immunomagnetic techniques for the enrichment and detection of isolated breast carcinoma cells in bone marrow and peripheral blood.[J].1997,6.
[18]Bernward Passlick,Boris Kubuschok,Jakob R Izbicki,etc.Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer[J].1999,68(6).
[19]Yoshimasa Maniwa,Masayoshi Okada,Noboru Ishii,etc.Vascular Endothelial Growth Factor Increased by Pulmonary Surgery Accelerates the Growth of Micrometastases in Metastatic Lung Cancer[J].1998,114(6).
[20]Moore MB,D'Amico TA,Lau CL,etc.Molecular staging of lung and esophageal cancer.[J].2002,82(3).
[21]Tezel C,Kosar A,Urek S,etc.The impact of immunohistochemical detection of positive lymph nodes in early stage lung cancer.[J].2006,54(2).
[22]Y H, Chen,W, Gao,T, Zhou,etc.Detection of bone marrow micrometastasis.[J].1999,18.
[23]Nozawa H,Kamesui T,Nozaki Z,etc.The predictive value of vascular endothelial growth factor and nm23 for the diagnosis of occult metastasis in non-small cell lung cancer.[J].2001,92(3).