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Relationship between tumor suppressor in lung cancer 1 and lung cancer
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF RESPIRATION
- Issue:
- 16
- DOI:
- 10.3760/cma.j.issn.1673-436X.2007.16.012
- Key Word:
- 抑癌基因;TSLC1;肺癌
Abstract： TSLC1是最近发现的一种抑癌基因,它的缺失、低表达与肺癌的发生、侵袭、转移及患者的预后密切相关.TSLC1的失活机制主要表现为甲基化和杂合性缺失;其抑癌机制与TSLC1的胞质区有很大关系,TSLC1所编码的蛋白质不仅与抑癌蛋白相结合发挥抑癌作用,而且还参与细胞之间的黏附作用和细胞信号的转导,对细胞周期进行了负调控,对肺癌的产生和发展起抑制作用,其抑癌作用机制不是完全清楚.
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