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Advances in study between ADAM family and tumors

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Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF RESPIRATION

Issue:: 16

DOI:: 10.3760/cma.j.issn.1673-436X.2007.16.010

Key Word:: 金属蛋白酶;整合素;肿瘤;表皮生长因子受体

Abstract： ADAM又称去整合素-金属蛋白酶,含有去整合素和金属蛋白酶功能结构域,具有细胞黏附和蛋白水解酶的功能,在细胞外基质的降解、细胞-细胞的黏连、细胞-基质的黏连、细胞融合及信号转导等细胞活动中具有重要作用,参与体内多种实体肿瘤形成、侵袭和转移等病理过程,在肿瘤的靶向治疗研究中可能具有重要价值.

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