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Effects of protein kinase C on the permeability of pulmonary microvascular endothelium
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF RESPIRATION
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1673-436X.2006.10.019
- Key Word:
- 蛋白激酶C;血管内皮细胞;通透性
Abstract： 早期急性呼吸窘迫综合征(ARDS)或急性肺损伤(ALI)是以肺毛细血管内皮细胞损伤和功能障碍导致水和蛋白向间质渗出增加为特点,而肺毛细血管内皮损伤后进一步损伤肺上皮细胞,导致肺损伤.引起肺血管内皮细胞损伤从而导致其通透性增加的因素很多,有活性氧物质(如过氧化氢H2O2),α-凝血酶,肿瘤坏死因子(TNF-α)等.蛋白激酶C(PKC)是介导其损伤作用的重要介质之一,但它们活化PKC的机制并不完全一样,PKC活化后引起血管内皮细胞损伤的机制也不尽相同.
- [1]HOUSE, COLIN,KEMP, BRUCE E..Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain.[J].1987,238(4834).
- [2]Dicorleto PE,Yang L,Walters A,etc.Role of CL-100, a Dual Specificity Phosphatase, in Thrombin-induced Endothelial Cell Activation.[J].2004,279(45).
- [3]Carden DL,Zhang S,Zhu Y,etc.Redox regulation of endothelial barrier integrity.[J].2001,281(4).
- [4]Park, J.H.,Okayama, N..Hypoxia/aglycemia increases endothelial permeability: Role of second messengers and cytoskeleton.[J].1999,277(6).
- [5]Claude A, Piantadosi,David A, Schwartz.The acute respiratory distress syndrome.[J].2004,141(6).
- [6]Yuan Y,Wu HM,Meng FY,etc.Tyrosine phosphorylation of paxillin/pp125FAK and microvascular endothelial barrier function.[J].1998,275(1 Pt.2).
- [7]Wang P,Kolosova IA,Ma SF,etc.Role of CPI-17 in the regulation of endothelial cytoskeleton.[J].2004,287(5).
- [8]Mehta D,Malik AB.Signaling mechanisms regulating endothelial permeability.[J].2006,86(1).
- [9]C G, Kevil,T, Oshima,B, Alexander,etc.H(2)O(2)-mediated permeability: role of MAPK and occludin.[J].2000,279(1).
- [10]Angelini GD,Shukla N,Muzaffar S,etc.Role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries.[J].2003,58(7).
- [11]Bazzoni G,Dejana E.Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis.[J].2004,84(3).
- [12]Judith Murray-Rust,Peter J. Parker.PKC at a glance[J].2004,117(2).
- [13]Mehta D,Rahman A,Malik AB.Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function.[J].2001,276(25).