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Involvement of class I phosphoinositide 3-kinases in neutrophil activation contributes to the pathogenesis of acute lung injury

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Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF RESPIRATION

Issue:: 10

DOI:: 10.3760/cma.j.issn.1673-436X.2006.10.011

Key Word:: 磷酸肌醇-3激酶;中性粒细胞;急性肺损伤;信号转导

Abstract：中性粒细胞肺内的大量浸润是急性肺损伤的主要病理特征之一,它能清除病原微生物等有害物质而发挥保护肺组织的作用,但若中性粒细胞大量的肺内浸润和过度的活化则可损伤肺组织,此负面作用在急性肺损伤的发生和发展中有重要的意义;磷酸肌醇-3激酶的信号转导途径在调节急性肺损伤患者中性粒细胞的细胞因子表达、呼吸爆发、趋化及凋亡有重要的作用.故了解其作用机制可能会从细胞分子水平为急性肺损伤的防治开辟新的途径.

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