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A study of plasmid-mediated resistance to quinolone

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Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF RESPIRATION

Issue:: 4

DOI:: 10.3760/cma.j.issn.1673-436X.2006.04.019

Key Word:: 喹喏酮类药物;耐药;质粒介导;qnr基因

Abstract：本文综述了质粒介导的喹诺酮类药物耐药菌的分子流行病学;质粒携带的qnr基因及其介导的喹喏酮类药物耐药机制;qnr基因表达对喹喏酮类药物活性的影响;qnr基因的表达不仅可单独引起细菌对喹喏酮类药物的耐药,还可明显增加其它耐药机制的作用,使细菌呈现多药耐药性.

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