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Interleukin-23 and the respiratory system disease
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF RESPIRATION
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1673-436X.2006.04.013
- Key Word:
- 白细胞介素23;T淋巴细胞;记忆性T细胞;γ干扰素;呼吸系统疾病
Abstract： IL-23是2000年发现的一种新的免疫调节因子,是IL-12家族的新成员.其主要的效应是刺激植物凝血素(phytohemagglutinin,PHA)激活的T细胞及记忆性T细胞增殖和产生IFN-γ.IL-23是一种维持慢性炎症和抵抗胞内细菌感染的重要的促炎因子,其与多种肺部疾病的免疫及疾病的形成有关如:肺结核、肺炎克雷白杆菌性肺炎、百日咳等感染性疾病及肺部纤维化;此外还与多种自身免疫性疾病及肿瘤的免疫有关.
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