You Position: Home > Paper
A study on the role of transforming growth factor-β on the airway wall remodeling in asthma
( views:88, downloads:8 )
- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF RESPIRATION
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1673-436X.2006.01.011
- Key Word:
- 转化生长因子-β;哮喘;气道重构
Abstract： 转化生长因子-β(TGF-β)是一个结构相关的生长因子大家族的一员,具有广泛调节细胞增殖、分化和凋亡等生物学功能.肺组织中多种细胞如肺泡巨噬细胞和肺纤维原细胞、上皮细胞、内皮细胞和平滑肌细胞均可合成TGF-β.发作期哮喘患者支气管肺泡灌洗液中以及在中度和重度哮喘患者气道黏膜活检标本中,TGF-β为过度表达.TGF-β可加重气道上皮的损害,刺激成纤维细胞、气道平滑肌细胞增殖,通过促进细胞外基质的合成、诱导结缔组织生长因子表达而导致气道上皮下纤维化,在哮喘的气道重构中具有重要的功能,因此针对TGF-β治疗成为防治哮喘气道重构新的研究方向.
- [1]Girolamo, Pelaia,Giovanni, Cuda,Alessandro, Vatrella,etc.Effects of transforming growth factor-[beta] and budesonide on mitogen-activated protein kinase activation and apoptosis in airway epithelial cells.[J].2003,29(1).
- [2]Wotton D,Massague J.Transcriptional control by the TGF-beta/Smad signaling system.[J].2000,19(8).
- [3]ten Dijke-P,Heldin CH,Miyazono K.Signaling inputs converge on nuclear effectors in TGF-beta signaling.[J].2000,25(2).
- [4]K, Miyazono,P, ten Dijke,C H, Heldin.TGF-beta signaling by Smad proteins.[J].2000,75.
- [5]Frossard N,Freund V,Duvernelle C.Transforming growth factor-beta and its role in asthma.[J].2003,16(4).
- [6]Nan-Shan Chang.TGF-β-Induced Matrix Proteins Inhibit p42/44 MAPK and JNK Activation and Suppress TNF-Mediated IκBα Degradation and NF-κB Nuclear Translocation in L929 Fibroblasts[J].2000,267(1).
- [7]Bhoola KD,Govinden R.Genealogy, expression, and cellular function of transforming growth factor-beta.[J].2003,98(2).
- [8]Roth M,King G,Burgess JK,etc.Expression of connective tissue growth factor in asthmatic airway smooth muscle cells.[J].2003,167(1).
- [9]P, Cohen,R, Rajah,J, Rosenbloom,etc.IGFBP-3 mediates TGF-beta1-induced cell growth in human airway smooth muscle cells.[J].2000,278(3).