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气道平滑肌细胞在哮喘气道重构时的增殖机制
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- Author:
- No author available
- Journal Title:
- SECTION OF RESPIRATORY SYSTEM FOREIGN MEDICAL SCIENCES
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1673-436X.2005.04.013
- Key Word:
- No keyword available
Abstract： @@ 传统的观点认为慢性气道炎症、可逆性气流阻塞和气道高反应性是支气管哮喘的三大特征.但近年大量的研究发现,哮喘患者经常出现不可逆或部分不可逆气流阻塞及持续的气道高反应性,目前医学界认为其原因是气道发生了改变即气道重构(airway remodeling)[1].其中气道平滑肌细胞(ASMC)增殖在气道重构中占有十分重要的地位,并与气道的高反应性和药物疗效密切相关.近年ASMC已成为哮喘研究的一个新热点,Hierst[2]提出应把ASMC作为哮喘研究的标靶.本文就ASMC的增殖机制的研究进展作一综述.
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