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Ⅱ类分泌型磷脂酶A2在急性肺损伤中的作用
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- Author:
- No author available
- Journal Title:
- SECTION OF RESPIRATORY SYSTEM FOREIGN MEDICAL SCIENCES
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1673-436X.2004.02.004
- Key Word:
- Ⅱ类分泌型磷脂酶A2;急性肺损伤;巨噬细胞;表面活性物质
Abstract： Ⅱ类分泌型磷脂酶A2(sPLA2-Ⅱ)在急性肺损伤(ALI)发病过程中,起了重要作用.sPLA2-Ⅱ在体内主要的细胞来源是巨噬细胞,在肺内的主要靶点是表面活性物质.sPLA2-Ⅱ在体内与表面活性物质及其代谢产物花生四烯酸、前列腺素之间相互作用,导致ALI时的恶性循环.sPLA2-Ⅱ通过细胞外信号调节激酶(ERK)和核因子-κB(NF-κB)途径刺激巨噬细胞内诱生型NO合酶(iNOS)的表达,损伤肺组织.抗sPLA2-Ⅱ策略为ALI的临床治疗提供了新的思路.
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