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Histopathologic process of pancreatic fibrosis in a chronic pancreatitis rat model induced by trinitrobenenze sulfonic acid(TNBS)
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PANCREATOLOGY
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-1935.2002.03.004
- Key Word:
- 三硝基苯磺酸;胰腺;纤维化
Abstract： 目的观察三硝基苯磺酸(TNBS)胰管内注射诱导大鼠慢性胰腺炎胰腺纤维化过程中的病理演变规律,进一步从病理学角度揭示其发生机制.方法通过胰管内注射含2% TNBS的乙醇磷酸盐缓冲液诱导大鼠慢性胰腺炎模型,对照组仅注射等体积乙醇磷酸盐缓冲液,并于术后72 h、3周、4周、5周、6周、7周处死大鼠.应用光镜、电镜观察不同时间点胰腺组织的病理学变化.结果 2%TNBS胰管注射后早期主要以胰腺组织炎症、水肿,腺泡细胞坏死等改变为主;3周后则以纤维化为主,主要表现为胰腺星状细胞活化和成纤维细胞增生,腺泡萎缩及间质内大量纤维沉积.结论胰管内注射TNBS引起的慢性胰腺炎的病理改变是基于胰腺实质急性损伤而发生的胰腺组织再生与修复,最终形成胰腺纤维化.
- [1]王兴鹏,龚自华,吴恺,等.慢性胰腺炎动物模型的建立[J].2001,(1).
- [2]龚自华,王兴鹏.胰腺星状细胞的研究进展[J].2001,(3).
- [3]张汝玲,王兴鹏.慢性胰腺炎胰腺纤维化发生机制及抗纤维化治疗进展[J].2001,(1).
- [4]H S, Li,J Y, Zhang,B S, Thompson,etc.Rat mitochondrial ATP synthase ATP5G3: cloning and upregulation in pancreas after chronic ethanol feeding.[J].2001,6.
- [5]Miyahara T,Nada O,Nawata H,etc.Morphological study of pancreatic endocrine in an experimental chronic pancreatitis with diabetes induced by stress and cerulein.[J].1999,23(3).
- [6]M V, Apte,P A, Phillips,R G, Fahmy,etc.Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells.[J].2000,118(4).