Melasma: the imbalance between epidermal barrier and melanin barrier

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SONG Xiu-zu(Department of Dermatology, Third People’s Hospital of Hangzhou, Hangzhou 310009, China)
XU Ai-e(Department of Dermatology, Third People’s Hospital of Hangzhou, Hangzhou 310009, China)
Journal Title:
International Journal of Dermatology and Venereology
Volume 38, Issue 05, 2012
Key Word:
Chloasma; Epidermal barrier; Melanocytes

Abstract: Melasma is an acquired skin disease characterized by facial hyperpigmentation of unclear pathogenesis.This paper describes the changes of epidermal barrier,melanin barrier and dermal blood vessels in melasma.On this basis,the pathogenesis of melasma is speculated to be associated with ultraviolet,cosmetics,contraceptives and other adverse stimuli,which cause epidermal barrier dysfunction,lead to a compensatory increase in melanocyte activity and melanin barrier followed by the occurrence of diseases characterized by skin pigmentation.Moreover,dermal telangiectasis is induced and vascular endothelial growth factor expression is enhanced,which accelerate skin pigmentation accordingly.

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