Mechanisms underlying the relationship between sun exposure and psoriasis
- Author:
- No author available
- Journal Title:
- International Journal of Dermatology and Venereology
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1673-4173.2012.05.012
- Key Word:
- 银屑病;日光;细胞凋亡;维生素D;Psoriasis;Sunlight;Apoptosis;Vitamin D
Abstract： Psoriasis is a common chronic inflammatory skin disease.The nature of psoriasis remains unanswered,and its development is generally attributed to the interaction between environmental and genetic factors.Sunlight,as one of the environmental factors,is closely relevant to the occurence and sequelae of psoriasis.Ultraviolet radiation can induce apoptosis in keratinocytes and modulate abnormal immune responses,and in turn relieve clinical symptoms of psoriasis.Further more,ultraviolet radiation can accelerate the regeneration of keratinocytes by promoting skin to produce vitamin D.However,uhraviolet is the most common pollutant that causes the production of reactive oxygen species.If the production of reactive oxygen species exceeds the antioxidant capacity of the host,psoriasis may be induced,which may partly explain the pathogenesis of photosensitive psoriasis.
- [1]刘瓦利,何伟.银屑病的病因与发病机制[J].2009,(8).
- [2]Sinéad, Dunphy,Clair M, Gardiner.NK cells and psoriasis.[J].2011,2011.
- [3]Gambichler T,Tigges C,Dith A,etc.Impact of etanercept treatment on ultraviolet B-induced inflammation, cell cycle regulation and DNA damage.[J].2011,164(1).
- [4]Timo, Buhl,Ullrich, Krüger,Steffen, Emmert,etc.Photosensitive psoriasis vulgaris inducible by a single suberythematous dose of ultraviolet B irradiation.[J].2008,88(4).
- [5]Hewison M.Vitamin D and the immune system: new perspectives on an old theme.[J].2010,39(2).
- [6]Schwarz A,Schwarz T,Maeda A,etc.Phenotypic and functional characterization of ultraviolet radiation-induced regulatory T cells.[J].2008,180(5).
- [7]E. Søyland,I. Heier,C. Rodríguez‐Gallego,etc.Sun exposure induces rapid immunological changes in skin and peripheral blood in patients with psoriasis[J].2011,164(2).
- [8]Charushila Y. Kadam,Adinath N. Suryakar,Rajesh D. Ankush,etc.Role of Oxidative Stress in Various Stages of Psoriasis[J].2010,25(4).
- [9]CEES G. M. KALLENBERG,MARC BIJL,ESTHER REEFMAN,etc.Apoptosis in Human Skin: Role in Pathogenesis of Various Diseases and Relevance for Therapy[J].2005,1051(jun).
- [10]全国银屑病流行调查组.全国1984年银屑病流行调查报告[J].1986,(5).
- [11]Attwa E,Swelam E.Relationship between smoking-induced oxidative stress and the clinical severity of psoriasis.[J].2011,25(7).
- [12]Cotterell L,Rutter KJ,Watson RE.Severely photosensitive psoriasis: a phenotypically defined patient subset.[J].2009,129(12).
- [13]Hart PH,Gorman S,Finlay Jones JJ.Modulation of the immune system by UV radiation: more than just the effects of vitamin D?[J].2011,11(9).
- [14]Liudmila Korkina,Saveria Pastore.Redox Imbalance in T Cell-Mediated Skin Diseases[J].2010,2010(Lioidmediators.).
- [15]Nickoloff BJ,Qin JZ,Nestle FO,etc.The cytokine and chemokine network in psoriasis.[J].2007,25(6).
- [16]Menter, A.,Korman, N. J.,Elmets, C. A.,etc.Guidelines of care for the management of psoriasis and psoriatic arthritis:Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy[J].2010,62(1).
- [17]Lowes, Michelle A.,Bowcock, Anne M..Pathogenesis and therapy of psoriasis.[J].2007,445(7130).
- [18]S P, Raychaudhuri,E M, Farber.The prevalence of psoriasis in the world.[J].2001,15(1).
- [19]Saraceno R,Mannheimer R,Chimenti S.Regional distribution of psoriasis in Italy.[J].2008,22(3).
- [20]Soyland E,Krogstad AL,Nilsen LT.Estimated ultraviolet doses to psoriasis patients during climate therapy.[J].2009,25(4).
- [21]Slade K,Shahriari M,Grant Kels JE,etc.Vitamin D and the skin.[J].2010,28(6).
- [22]Delibas N,Yildirim M,Inaloz HS,etc.The role of oxidants and antioxidants in psoriasis.[J].2003,17(1).
- [23]Gallo RL,Miller J.Vitamin D and innate immunity.[J].2010,23(1).
- [24]Ghoreschi K,Weigert C,Rocken M.Immunopathogenesis and role of T cells in psoriasis.[J].2007,25(6).
- [25]Valdimarsson H,Johnston A,Gudjonsson JE,etc.Narrowband-UVB irradiation decreases the production of pro-inflammatory cytokines by stimulated T cells.[J].2005,297(1).