You Position: Home > Paper
The diagnosis and treatment of central nervous system lymphoma
( views:524, downloads:345 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1009-9921.2008.01.002
- Key Word:
- 淋巴瘤;中枢神经系统;诊断;治疗
Abstract： 通常中枢神经系统淋巴瘤(CNSL)是指继发性淋巴瘤,以非霍奇金淋巴瘤(NHL)多见.CNSL临床表现多样化,与受累部位有关,常出现颅神经麻痹(易侵犯颅神经Ⅲ、Ⅳ、Ⅵ和Ⅶ)、头痛及性格改变等症状.影像学及脑脊液检查有助于CNSL的诊断及与颅内感染、脑血管病及治疗相关性颅内病变等的鉴别诊断.易发生中枢神经系统侵犯的高危因素有临床分期Ⅲ～Ⅳ期、伴结外浸润、国际预后评价指标(IPI)评分高及2倍以上乳酸脱氢酶(LDH)水平增高等.病理类型中,特别是原淋巴细胞型和Buikitt淋巴瘤,是最易发生中枢神经系统侵犯的病理类型,上述两种类型必须接受预防性治疗.目前常规采用的治疗方案为鞘内给药:单药甲氨蝶呤(MTX)到三药联合治疗[MTX、地塞米松(DXM)和阿糖胞苷(Ara-C)]及联合系统化疗、放疗.自体或异基因造血干细胞移植治疗CNSL的应用价值不确定.
- [1]F R, MacKintosh,T V, Colby,W J, Podolsky,etc.Central nervous system involvement in non-Hodgkin's lymphoma: an analysis of 105 cases.[J].1982,49(3).
- [2]Terol MJ,Graus F,Campo E,etc.CNS involvement in mantle-cell lymphoma.[J].1996,14(3).
- [3]Virion JM,Marit G,Haioun C,etc.Incidence and risk factors for central nervous system occurrence in elderly patients with diffuse large-B-cell lymphoma: influence of rituximab.[J].2004,15(1).
- [4]Abrams RA,Morrison C,Jones RJ,etc.High-dose therapy and blood or marrow transplantation for non-Hodgkin lymphoma with central nervous system involvement.[J].2005,11(2).
- [5]Upendra, Hegde,Armando, Filie,Richard F, Little,etc.High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphomas at risk for central nervous system involvement: the role of flow cytometry versus cytology.[J].2005,105(2).
- [6]Recht L,Glantz M,Colocci N.Prevention and treatment of central nervous system involvement by non-Hodgkin's lymphoma: a review of the literature.[J].2004,24(4).
- [7]Nome O,Skovlund E,Lote K,etc.Central nervous system involvement following diagnosis of non-Hodgkin's lymphoma: a risk model.[J].2002,13(7).
- [8]M D, Sapozink,H S, Kaplan.Intracranial Hodgkin's disease. A report of 12 cases and review of the literature.[J].1983,52(7).