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Study on the expression of heat shock protien 70 gene and protein in adult lymphocyte of human acute leukemia
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-9921.2005.03.005
- Key Word:
- 成人急性淋巴细胞白血病;热休克蛋白70;蛋白印迹;RT-PCR
Abstract： 目的研究热休克蛋白70(HSP70)在成人急性淋巴细胞白血病中的表达.方法RT-PCR法和Westrn blot法检测急性淋巴细胞白血病化疗前、化疗后及正常人HSP70 mRNA及HSP70蛋白的表达.结果成人急性淋巴细胞白血病化疗前HSP70 mRNA及HSP70的蛋白表达明显低于正常人(P＜0.05),化疗后明显高于正常人(P＜0.05).结论化疗后能明显提高急性淋巴细胞白血病患者HSP70基因转录和蛋白的表达,而对癌细胞则起保护作用.
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