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STUDY ON THE SIGNIFICANCE OF TGF- β1 AND ITS RECEPTOR EXPRESSION IN LEUKEMIC PATIENTS
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1009-9921.2004.06.006
- Key Word:
- 白血病;TGF-β;受体
Abstract： 目的:探讨白血病患者TGF-β1及其受体表达在白血病发展过程中的意义.方法:用免疫组织化学或ELISA法检测白血病患者不同病程时期外周血、骨髓以及骨髓基质细胞的结合型TGF-β1,TGFRⅡ和可溶性TGF-β1.结果:初诊患者外周血结合型TGFRⅡ和可溶性TGF-β1含量明显下降,缓解后又升高至接近正常,结合型TGF-β1表达无明显异常.骨髓有核细胞的结合型TGFRⅡ表达情况与外周血基本一致,初诊患者明显下降,缓解后又升高.初诊患者的骨髓基质细胞生长不良,结合型和可溶性TGF-β1含量均明显低下,缓解后又趋于升高,但骨髓基质细胞TGFRⅡ未见明显异常.结论:白血病骨髓基质细胞的TGF-β1表达低下,可能是其外周血和骨髓中TGF-β1含量下降的重要原因,而白血病患者TGF-β1下降及TGFRⅡ表达低下,可能是白血病细胞得以大量增生的重要原因.
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